Can Bacillus paranthracis cause bacteremia in a T-ALL patient? WGS-based diagnosis

Can Bacillus paranthracis cause bacteremia in a T-ALL patient? WGS-based diagnosis

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Introduction: Most of Bacillus spp.generally avirulent species in healthy patients, but if there is a fragile in the patient, especially their immune system, Bacillus spp.can be an agent for infections.

Case Report: In this case, we report that Bacillus paranthracis, diagnosed by whole genome ACCESSORIES HATS sequencing, is responsible for bacteremia in a T-ALL patient.A 26-year-old male patient was diagnosed with T-cell acute lymphoblastic leukemia.Bacillus paranthracis was isolated from two sets of blood cultures obtained from a patient with febrile neutropenia.

Results: The bacteria was identified as Bacillus cereus group in a routine microbiology laboratory by MALDI TOF MS.Then whole genome sequencing (WGS) confirmed its name as Bacillus paranthracis.The pathogenicity of the bacterium, especially Ski de fond - Enfant - Bottes - Combi in immunocompromised patients, has also been demonstrated by WGS.

Conclusions: In a microbiology laboratory, the use of Whole Genome Sequencing (WGS) is important for diagnosing diseases, especially in immunocompromised patients.It will serve the management of these patients for infection control.